Seminars in Thoracic and Cardiovascular Surgery
Volume 14, Issue 3 , Pages 239-249 , July 2002

The solitary pulmonary nodule: A primer on differential diagnosis

References 

  1. Shankar PS. Solitary pulmonary nodule: A clinical approach. Lung India. 1988;6:175–176
  2. Holin SM, Dorek RE, Glaser S, et al.  Solitary pulmonary nodules found in a community-wide chest roentgenographic survey. Am Rev Tubercul. 1959;79:427–439
  3. Davis EW, Peabody J, Katz S. Solitary pulmonary nodule. J Thorac Cardiovasc Surg. 1959;32:728–771
  4. Nathan MH, Collins VP, Adams RA. Differentiation of benign and malignant pulmonary nodules by growth rate. Radiology. 1962;79:221–231
  5. Neff TA. To needle, brush, cut or watch?. Chest. 1973;63:134
  6. Neff TA. The science and humanity of the solitary pulmonary nodule. Am Rev Respir Dis. 1986;134:433–434
  7. Cummings SR, Lillington GA, Richard RJ. Managing solitary pulmonary nodules: The choice of strategy is a close call. Am Rev Respir Dis. 1986;134:453–460
  8. Siegelman SS, Zerhouni EA, Leo FP, et al.  CT of the solitary pulmonary nodule. Am J Roentgenol. 1980;135:1–13
  9. Zerhouni EA, Boukadoum M, Siddiky MA, et al.  A standard phantom for quantitative CT analysis of pulmonary nodules. Radiology. 1983;149:767–773
  10. Munden RF, Hess KR. “Ditzels” on chest CT: Survey of members of the Thoracic Society of Radiology. Am J Roentgenol. 2001;176:1363–1369
  11. Yankelevitz DF, Reeves AP, Costis WJ, et al.  Small pulmonary nodules: Volumetically determined growth based on CT evaluation. Radiology. 2000;217:251–256
  12. Stoller JK, Ahmad M, Rice TW. Solitary pulmonary nodule. Cleve Clin J Med. 1988;55:68–74
  13. Lillington GA. Management of solitary pulmonary nodules. Disease-A-Month. May 1991;37:271–318
  14. Siegelman SS, Khouri LP, Frank EK, et al.  Solitary pulmonary nodules: Assessment. Radiology. 1986;160:307–312
  15. Higgins GA, Shields TW, Keehm RJ. The solitary pulmonary nodule: Ten-year follow-up of the Veterans Administration Armed Forces Cooperative Study. Arch Surg. 1975;110:570–575
  16. Ray JF, Lawton BR, Magnin GE, et al.  The coin lesion story: Update 1976, twenty's experience with early thoracotomy for 179 suspected malignant coin lesions. Chest. 1976;70:332–336
  17. Khouri NF, Meziane MA, Zerhouni EA, et al.  The solitary pulmonary nodule: Assessment, diagnosis, and management. Chest. 1987;91:128–133
  18. Swensen SJ, Jett JR, Payne WS, et al.  An integrated approach to evaluation of the solitary pulmonary nodule. Mayo Clin Proc. 1990;65:173–186
  19. Toomes H, Delphendahl A, Manke HG, et al.  The coin lesion of the lung: A review of 995 resected coin lesions. Cancer. 1983;51:534–537
  20. Libby DM, Henschke CI, Yankelevitz DF. The solitary pulmonary nodule: Update 1995. Am J Med. 1995;99:491–496
  21. Oat D, Fein A. Evaluation and management of the solitary pulmonary nodule. Am J Respir Crit Care Med. 2000;162:782–787
  22. Gurney JW. Determining the likelihood of malignancy in solitary pulmonary nodules with Bayesian analysis. Part I: Theory. Radiology. 1993;186:405–413
  23. Webb R. Radiologic evaluation of the solitary pulmonary nodule. Am J Roentgenol. 1990;154:708–710
  24. Berger WG, Erly WK, Krupinski EA, et al.  The solitary pulmonary nodule on chest radiography: Can we really tell if the nodule is calcified?. Am J Roentgenol. 2001;176:201–204
  25. Cummings SR, Lillington GA, Richard RJ. Estimating the probability of malignancy in solitary pulmonary nodules: A Bayesian approach. Am Rev Respir Dis. 1986;134:449–452
  26. Caskey CI, Templeton PA, Zerhouni EA. Current evaluation of the solitary pulmonary nodule. Radiol Clin North Am. 1990;28:511–520
  27. Henschke CI, Yankelevitz D, Westcott J, et al.  Work-up of the solitary pulmonary nodule. American College of Radiology appropriateness criteria. Radiology. 2001;215(suppl):607–609
  28. Strider JN, Laforet EG, Lynch JP. The surgery of pulmonary tuberculosis. N Engl J Med. 2000;176:960–965
  29. Goodwin RA, Des Prez RM. Histoplasmosis. Am Rev Respir Dis. 1978;117:929–956
  30. Fullerton DA. Coccidioidomycosis. Chest Surg Clin N Am. 1993;3:607–625
  31. Allen MS, Trastek VF, Deschams C, et al.  Blastomycosis. Chest Surg Clin N Am. 1993;3:627–638
  32. Hopeman AR. Cryptococcus. Chest Surg Clin N Am. 1993;3:589–605
  33. Macher A. Histoplasmosis and blastomyocosis. Med Clin N Am. 1980;65:447–459
  34. De Schamps L, Ailia MS, Daly RL, et al.  Histoplasmosis. Chest Surg Clin N Am. 1993;3:639–651
  35. Edwards LD, Acquaviva FA, Livesay VT, et al.  An atlas of sensitivity to tuberculin PPD and histoplasmosis in the United States. Am Rev Respir Dis. 1969;90(suppl):1–132
  36. Read CT. Coin lesion, pulmonary: In the southwest (solitary pulmonary nodule). Ariz Med. 1972;29:775–781
  37. Pritzker HG, MacKay JS. Pulmonary actinomycosis stimulating bronchogenic carcinoma. Can Med Assoc J. 1963;88:785–791
  38. Tedder NM, Wolfe WG. Actinomyocosis and nocardial infiltrates. Chest Surg Clin N Am. 1993;3:653–667
  39. Rocai J. Ackerman's Surgical Pathology. In: ed 8. St. Louis, MO: Mosby; 1996;p. 362
  40. Suen HC, Wright CD, Mathisen DJ. Surgical management of pulmonary aspergillious. Chest Surg Clin N Am. 1993;3:671–681
  41. Wong K, Waters CM, Walesby RK. Surgical management of invasive pulmonary aspergillous in immunocompromised patients. Eur J Cardiothorac Surg. 1993;6:138–143
  42. Patchefsky AS. Nonneoplastic Pulmonary Disease. In: Ed 3.  Sternberg SS editors. Diagnostic Surgical Pathology. Vol. 1:Philadelphia, PA: Lippincott, Williams and Wilkins; 1999;p. 1011–1115
  43. Lacronique J, Bernaudin JF, Soler P, et al.  Alveolitis and granulomas; sequential course in pulmonary sarcoidosis. In:  Chretien J, et al. editor. Sarcoidosis and Other Granulomatous Disorders. Ninth International Conference on Sarcoidosis and Other Granulomatous Disorders. Paris, France: Pergamon; 1986;p. 36–42
  44. James DG, Neville E, Siltzbach LE. A worldwide review of sarcoidosis. Ann N Y Acad Sci. 1976;278:321–334
  45. Patchefsky AS. Nonneoplastic Pulmonary Disease. In: Ed 3.  Sternberg SS editors. Diagnostic Surgical Pathology. Vol. 1:Philadelphia, PA: Lippincott, Williams and Wilkins; 1999;p. 1011–1115
  46. Hui AN, Koss MN, Hochholzer L, et al.  Amyloid presenting in the lower respiratory tract. Arch Pathol Lab Med. 1986;110:212–218
  47. Thompson PJ, Citron KM. Amyloid and the lower respiratory tract. Thorax. 1983;38:84–87
  48. Rubinow A, Celli BR, Cohen AS, et al.  Localized amyloidosis of the lower respiratory tract. Am Rev Respir Dis. 1978;118:603–611
  49. Rocai J. Ackerman's Surgical Pathology. In: ed 8. St. Louis, MO: Mosby; 1996;p. 391
  50. Butler C, Kleinerman J. Pulmonary hamartoma. Arch Pathol. 1969;88:584–592
  51. Patchefsky AS. Nonneoplastic Pulmonary Disease. In: Ed 3.  Sternberg SS editors. Diagnostic Surgical Pathology. Vol. 1:Philadelphia, PA: Lippincott, Williams and Wilkins; 1999;p. 1011–1115
  52. Nicholson AG, Wotherspoon AC, Diss TC, et al.  Reactive pulmonary lymphoid disorders. Histopathology. 1995;26:405–412
  53. Koss MN. Pulmonary lymphoid disorders. Semin Diagn Pathol. 1995;12:158–171
  54. Saldana MJ, Mosnes JM. Lymphoid interstitial pneumonia in HIV infected individuals. Prog Surg Pathol. 1992;12:181–215
  55. James DG, Neville E, Siltzbach LE. A worldwide review of sarcoidosis. Ann N Y Acad Sci. 1976;278:1102
  56. Klein JS, Fischbein NJ. The Lung. In:  Brant WE,  Helms CA editor. Fundamentals of Diagnostic Radiology. Baltimore, MD: Williams and Wilkins,; 1994;p. 412–494
  57. Umiker WO, Iverson L. Postinflammatory “tumors” of the lung: Report of four cases simulating xanthoma, fibroma or plasma cell tumor. J Thorac Surg. 1954;28:55–63
  58. Patel AM, Davila DG, Peter SG. Paraneoplastic syndromes associated with lung cancer. Mayo Clin Proc. 1993;68:278–287
  59. Rocai J. In: Ed 8. Respiratory Tract, Lungs and Pleura, Ackerman's Surgical Pathology. Vol. 1:St. Louis, MO: Mosby Year Book, Inc; 1996;p. 289–434
  60. Rocai J. In: Ed 8. Respiratory Tract, Lungs and Pleura, Ackerman's Surgical Pathology. Vol. 1:St. Louis, MO: Mosby Year Book, Inc; 1996;p. 289–434
  61. Aisner J, Belani C. Lung cancer. Recent changes and expectations of improvements. Semin Oncol. 1993;20:383–393
  62. Auerbach O, Gere JB, Forman JB, et al.  Changes in the bronchial epithelium in relation to smoking and cancer of the lung. N Engl J Med. 1957;256:97–104
  63. Peters EJ, Morice R, Benner SE, et al.  Squamous metaplasia of the bronchial mucosa and its relationship to smoking. Chest. 1993;103:1429–1432
  64. Travis WD, Travis LB, Devesa SS. Lung cancer. Cancer. 1995;75:191–202
  65. Kung IT, Liu IO, Loke SL, et al.  Pulmonary scar cancer. A pathologic reappraisal. Am J Pathol. 1985;9:391–400
  66. Cox JD, Yesner RA. Adenocarcinoma of the lung. Recent results from the Veterans Administration Lung Group. Am Rev Respir Dis. 1979;120:1025–1029
  67. Valaitis J, Warren S, Gamble D. Increasing incidence of adenocarcinoma of the lung. Cancer. 1981;47:1042–1046
  68. Barsky SH, Huang SJ, Bhuta S. The extracellular matrix of pulmonary scar carcinomas is suggestive of a desmoplastic origin. Am J Pathol. 1986;124:412–449
  69. Cagle PT, Cohle SD, Greenberg SD. Natural history of pulmonary scar cancer. Clinical and pathological implications. Cancer. 1985;56:2031–2035
  70. Madri JA, Carter D. Scar cancers of the lung. Origin and significance. Hum Pathol. 1984;15:625–631
  71. Daly RC, Trastek VF, Pairolero PC, et al.  Bronchiolalveolar carcinoma. Factors affecting survival. Ann Thorac Surg. 1991;51:368–377
  72. Donaldson JC, Kaminsky DB, Elliott RC. Bronchiolar carcinoma. Report of 11 cases and review of the literature. Cancer. 1978;41:250–258
  73. Greco RJ, Steiner RM, Goldman S, et al.  Bronchoalveolar cell carcinoma of the lung. Ann Thorac Surg. 1986;41:652–656
  74. Manning JT, Spjut HJ, Tschen JA. Bronchioloalveolar carcinoma. The significance of two histopathologic types. Cancer. 1984;54:525–534
  75. Tao LC, Delarue NC, Sanders D, et al.  Bronchiolo-alveolar carcinoma. A correlative clinical and cytologic study. Cancer. 1978;42:2759–2767
  76. Ishida T, Kaneko S, Tateishi M, et al.  Large cell carcinoma of the lung. Prognostic implications of histopathologic and immunohistochemical subtyping. Am J Clin Pathol. 1990;93:176–182
  77. Yesner R. Large cell carcinoma of the lung. Semin Diagn Pathol. 1985;2:255–269
  78. Patchefsky AS. Nonneoplastic Pulmonary Disease. In: Ed 3.  Sternberg SS editors. Diagnostic Surgical Pathology. Vol. 1:Philadelphia, PA: Lippincott, Williams and Wilkins; 1999;p. 1011–1115
  79. Shimasato Y. Lung cancer: Its histogenesis, differentiation and prognostic factors. Trans Soc Pathol Jpn. 1983;72:29–57
  80. Naruke T, Goya T, Tsuchiya R, et al.  Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg. 1988;96:440–447
  81. National Cancer Center Hospital . In: Cancer of the lung: Diagnosis and treatment. vol 2:Tokyo, Japan: Kodansha; 1983;p. 91–103
  82. Radice PA, Matthews MJ, Ihde DC, et al.  The clinical behavior of “mixed” small cell/large cell bronchogenic carcinoma compared to “pure” small cell subtypes. Cancer. 1982;50:2894–2902
  83. Takamori S, Noguchi M, Morinaga S, et al.  Clinicopathologic characteristics of adenosquamous carcinoma of the lung. Cancer. 1991;67:649–654
  84. Bergmann M, Ackerman LV, Kemler RL. Carcinosarcoma of the lung: Review of the literature and report of two cases treated by pneumonectomy. Cancer. 1951;4:919–929
  85. Barnard WG. Embryoma of the lung. Thorax. 1952;7:229–301
  86. Bonikos DS, Bensche KG, Jamplis RW. Peripheral pulmonary carcinoid tumors. Cancer. 1976;37:1977–1998
  87. Ranchod M, Levine GD. Spindle-cell carcinoid tumors of the lung. A clinico-pathologic study of 35 cases. Am J Surg Pathol. 1980;4:315–331
  88. Arrigoni MG, Woolner LB, Bernatz PE. Atypical carcinoid tumors of the lung. J Thorac Cardiovasc Surg. 1972;64:413–421
  89. Travis WD, Linnoila RI, Tsokos MG, et al.  Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural immunohistochemical, and flow cytometric study of 35 cases. Am J Surg Pathol. 1991;15:529–553
  90. Wilkins EW, Grillo HC, Monecure AC, et al.  Changing times in surgical management of bronchopulmonary carcinoid tumor. Ann Thorac Surg. 1984;38:339–344
  91. Nash G, Fligiel S. Kaposi's sarcoma presenting as pulmonary disease in the acquired immunodeficiency syndrome. Diagnosis by lung biopsy. Hum Pathol. 1984;15:999–1001
  92. Purdy LJ, Colby TV, Yousem SA, et al.  Pulmonary Kaposi's sarcoma. Premortem histologic diagnosis. Am J Surg Pathol. 1986;10:301–311
  93. Patel AM, Ryu JH. Angiosarcoma in the lung. Chest. 1993;103:1531–1535
  94. Yousem SA. Angiosarcoma presenting in the lung. Arch Pathol Lab Med. 1986;110:112–115
  95. Cordier JF, Chailleux E, Lauque D, et al.  Primary pulmonary lymphomas. A clinical study of 70 cases in nonimmunocompromised patients. Chest. 1993;103:201–208
  96. Radin AI. Primary pulmonary Hodgkin's disease. Cancer. 1990;65:550–563
  97. Herbert A, Wright DH, Isaacson PG, et al.  Primary malignant lymphoma of the lung. Histopathologic and immunologic evaluation of nice cases. Hum Pathol. 1984;15:415–422
  98. Kennedy JL, Nathwani BN, Burke JS, et al.  Pulmonary lymphomas and other pulmonary lymphoid lesions: A clinicopathologic and immunologic study of 64 patients. Cancer. 1985;56:539–552
  99. Weiss LM, Yousem SA, Warnke RA. Non-Hodgkin's lymphomas of the lung. A study of 19 cases emphasizing the utility of frozen section immunologic studies in differential diagnosis. Am J Surg Pathol. 1985;9:480–490
  100. Addis BJ, Hyjek E, Isaacson PG. Primary pulmonary lymphoma. A reappraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology. 1988;13:1–17
  101. Chetty R, Close PM, Timme AH, et al.  Primary biphasic lymphoplasmacytic lymphoma of the lung. A mucosa-associated lymphoid tissue lymphoma with compartmentalization of plasma cells in the lung and lymph nodes. Cancer. 1992;69:1124–1129
  102. Kradin RL, Young RH, Kradin LA, et al.  Immunoblastic lymphoma arising in chronic lymphoid hyperplasia of the pulmonary interstitium. Cancer. 1982;50:1339–1343
  103. Cahan W, Shah H, Castro E. Benign solitary lung lesions in patients with cancer. Ann Surg. 1978;187:241–244
  104. Quint IE, Park CH, Iannoettoni MD. Solitary pulmonary nodules in patients with extrapulmonary neoplasms. Radiology. 2000;217:257–261

☆ Address reprint requests to Sudish Murthy MD, PhD, Cleveland Clinic Foundation, Department of Thoracic and Cardiovascular Surgery, Desk F24, 9500 Euclid Ave., Cleveland, OH 44195.

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Seminars in Thoracic and Cardiovascular Surgery
Volume 14, Issue 3 , Pages 239-249 , July 2002

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