Seminars in Thoracic and Cardiovascular Surgery
Volume 17, Issue 4 , Pages 348-360 , Winter 2005

Cell Therapy for Heart Failure—Muscle, Bone Marrow, Blood, and Cardiac-Derived Stem Cells

  • Harald C. Ott, MD

      Affiliations

    • Center for Cardiovascular Repair, University of Minnesota, Minneapolis, Minnesota.
    • ,
  • Bryce H. Davis, BSE

      Affiliations

    • Department of Biomedical Engineering, Duke University, Durham, North Carolina.
    • ,
  • Doris A. Taylor, PhD

      Affiliations

    • Center for Cardiovascular Repair, University of Minnesota, Minneapolis, Minnesota.
    • Corresponding Author InformationAddress reprint requests to: Doris A Taylor, PhD, Center for Cardiovascular Repair, University of Minnesota, 312 Church Street SE, NHH 7-105A, Minneapolis MN 55455.

References 

  1. Miller LW , Missov ED . Epidemiology of heart failure . Cardiol Clin . 2001;19:547–555
  2. World Health Report. In www.who.int/whr/en/; 2003
  3. Cohn JN , Francis GS . Cardiac failure (a revised paradigm) . J Card Fail . 1995;1:261–266
  4. Moss AJ , Zareba W , Hall WJ , et al.   Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction . N Engl J Med . 2002;346:877–883
  5. Moss AJ , Hall WJ , Cannom DS , et al.  Multicenter Automatic Defibrillator Implantation Trial Investigators   Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia . N Engl J Med . 1996;335:1933–1940
  6. Cohn JN . Structural basis for heart failure. Ventricular remodeling and its pharmacological inhibition . Circulation . 1995;91:2504–2507
  7. Cohn JN , Ferrari R , Sharpe N . Cardiac remodeling—concepts and clinical implications (a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling) . J Am Coll Cardiol . 2000;35:569–582
  8. Hertz MI , Taylor DO , Trulock EP , et al.   The registry of the international society for heart and lung transplantation (nineteenth official report—2002) . J Heart Lung Transplant . 2002;21:950–970
  9. Rose EA , Gelijns AC , Moskowitz AJ , et al.   Long-term mechanical left ventricular assistance for end-stage heart failure . N Engl J Med . 2001;345:1435–1443
  10. Bank AJ , Mir SH , Nguyen DQ , et al.   Effects of left ventricular assist devices on outcomes in patients undergoing heart transplantation . Ann Thorac Surg . 2000;69:1369–1374 discussion, 1375
  11. Lietz K , Miller LW . Will left-ventricular assist device therapy replace heart transplantation in the foreseeable future? . Curr Opin Cardiol . 2005;20:132–137
  12. Miller LW . Patient selection for the use of ventricular assist devices as a bridge to transplantation . Ann Thorac Surg . 2003;75:S66–S71
  13. Stevenson LW , Miller LW , Desvigne-Nickens P , et al.   Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy (a subset analysis from REMATCH (Randomized Evaluation of Mechanical Assistance in Treatment of Chronic Heart Failure)) . Circulation . 2004;110:975–981
  14. Mancini DM , Beniaminovitz A , Levin H , et al.   Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure . Circulation . 1998;98:2383–2389
  15. Taylor DA , Atkins BZ , Hungspreugs P , et al.   Regenerating functional myocardium (improved performance after skeletal myoblast transplantation) . Nat Med . 1998;4:929–933
  16. Taylor D . 2nd Gene and Stem Cell Therapy Conference; Valladolid, Spain, in 2nd Gene and Stem Cell Therapy Conference . 2005; Valladolid, Spain
  17. Chachques JC , Grandjean PA , Tommasi JJ , et al.   Dynamic cardiomyoplasty (a new approach to assist chronic myocardial failure) . Life Support Syst . 1987;5:323–327
  18. Koh GY , Klug MG , Soonpaa MH , et al.   Differentiation and long-term survival of C2C12 myoblast grafts in heart . J Clin Invest . 1993;92:1548–1554
  19. Mauro A . Satellite cell of skeletal muscle fibers . J Biophys Biochem Cytol . 1961;9:493–495
  20. Zibaitis A , Greentree D , Ma F , et al.   Myocardial regeneration with satellite cell implantation . Transplant Proc . 1994;26:3294
  21. Atkins BZ , Lewis CW , Kraus WE , et al.   Intracardiac transplantation of skeletal myoblasts yields two populations of striated cells in situ . Ann Thorac Surg . 1999;67:124–129
  22. Murry CE , Wiseman RW , Schwartz SM , et al.   Skeletal myoblast transplantation for repair of myocardial necrosis . J Clin Invest . 1996;98:2512–2523
  23. Tremblay JP , Roy B , Goulet M . Human myoblast transplantation (a simple assay for tumorigenicity) . Neuromuscul Disord . 1991;1:341–343
  24. Field L . Future therapy for cardiovascular disease . NHLBI Workshop Cell Transplantation (Future Therapy for Cardiovascular Disease?) . 1998; Columbia, MD
  25. Menasche P , Hagege AA , Vilquin JT , et al.   Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction . J Am Coll Cardiol . 2003;41:1078–1083
  26. Suzuki K , Brand NJ , Allen S , et al.   Overexpression of connexin 43 in skeletal myoblasts (Relevance to cell transplantation to the heart) . J Thorac Cardiovasc Surg . 2001;122:759–766
  27. Siminiak T , Fiszer D , Jerzykowska O , et al.   Percutaneous trans-coronary-venous transplantation of autologous skeletal myoblasts in the treatment of post-infarction myocardial contractility impairment (the POZNAN trial) . Eur Heart J . 2005;26:1188–1195
  28. Chachques JC , Herreros J , Trainini J , et al.   Autologous human serum for cell culture avoids the implantation of cardioverter-defibrillators in cellular cardiomyoplasty . Int J Cardiol . 2004;95(suppl 1):S29–S33
  29. Yeh ET , Zhang S , Wu HD , et al.   Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo . Circulation . 2003;108:2070–2073
  30. Murry CE , Soonpaa MH , Reinecke H , et al.   Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts . Nature . 2004;428:664–668
  31. Deten A , Volz HC , Clamors S , et al.   Hematopoietic stem cells do not repair the infarcted mouse heart . Cardiovasc Res . 2005;65:52–63
  32. Jiang Y , Jahagirdar BN , Reinhardt RL , et al.   Pluripotency of mesenchymal stem cells derived from adult marrow . Nature . 2002;418:41–49
  33. Verfaillie CM , Pera MF , Lansdorp PM . Stem cells (hype and reality) . Hematology (Am Soc Hematol Educ Program) . 2002;369–391
  34. Hu Y , Wang QY , Ma L , et al.   [Identification and isolation of mesenchymal stem cells from human fetal pancreas] . Zhongguo Yi Xue Ke Xue Yuan Xue Bao . 2002;24:45–49
  35. Kawada H , Fujita J , Kinjo K , et al.   Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction . Blood . 2004;104:3581–3587
  36. Strauer BE , Brehm M , Zeus T , et al.   Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans . Circulation . 2002;106:1913–1918
  37. Schuster MD , Kocher AA , Seki T , et al.   Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration . Am J Physiol Heart Circ Physiol . 2004;287:H525–H532
  38. Kocher AA , Schuster MD , Szabolcs MJ , et al.   Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function . Nat Med . 2001;7:430–436
  39. Thompson RB , van den Bos EJ , Davis BH , et al.   Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation . J Heart Lung Transplant . 2005;24:205–214
  40. Thompson RB , Emani SM , Davis BH , et al.   Comparison of intracardiac cell transplantation (autologous skeletal myoblasts versus bone marrow cells) . Circulation . 2003;108(suppl 1):II264–II271
  41. Bittira B , Shum-Tim D , Al-Khaldi A , et al.   Mobilization and homing of bone marrow stromal cells in myocardial infarction . Eur J Cardiothorac Surg . 2003;24:393–398
  42. Vulliet PR , Greeley M , Halloran SM , et al.   Intracoronary arterial injection of mesenchymal stromal cells and microinfarction in dogs . Lancet . 2004;363:783–784
  43. Jiang XX , Zhang Y , Liu B , et al.   Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells . Blood . 2005;105:4120–4126
  44. Kalka C , Masuda H , Takahashi T , et al.   Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization . Proc Natl Acad Sci USA . 2000;97:3422–3427
  45. Shintani S , Murohara T , Ikeda H , et al.   Mobilization of endothelial progenitor cells in patients with acute myocardial infarction . Circulation . 2001;103:2776–2779
  46. Aicher A , Brenner W , Zuhayra M , et al.   Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling . Circulation . 2003;107:2134–2139
  47. Kawamoto A , Gwon HC , Iwaguro H , et al.   Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia . Circulation . 2001;103:634–637
  48. Masuda H , Kalka C , Asahara T . Endothelial progenitor cells for regeneration . Hum Cell . 2000;13:153–160
  49. Urbich C , Knau A , Fichtlscherer S , et al.   FOXO-dependent expression of the proapoptotic protein Bim (pivotal role for apoptosis signaling in endothelial progenitor cells) . FASEB J . 2005;19:974–976
  50. Khakoo AY , Finkel T . Endothelial progenitor cells . Annu Rev Med . 2005;56:79–101
  51. Schmidt-Lucke C , Rossig L , Fichtlscherer S , et al.   Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events (proof of concept for the clinical importance of endogenous vascular repair) . Circulation . 2005;111:2981–2987
  52. Rauscher FM , Goldschmidt-Clermont PJ , Davis BH , et al.   Aging, progenitor cell exhaustion, and atherosclerosis . Circulation . 2003;108:457–463
  53. Henning RJ , Abu-Ali H , Balis JU , et al.   Human umbilical cord blood mononuclear cells for the treatment of acute myocardial infarction . Cell Transplant . 2004;13:729–739
  54. Ma N , Stamm C , Kaminski A , et al.   Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice . Cardiovasc Res . 2005;66:45–54
  55. Laugwitz KL , Moretti A , Lam J , et al.   Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages . Nature . 2005;433:647–653
  56. Anversa P , Nadal-Ginard B . Myocyte renewal and ventricular remodelling . Nature . 2002;415:240–243
  57. Beltrami AP , Barlucchi L , Torella D , et al.   Adult cardiac stem cells are multipotent and support myocardial regeneration . Cell . 2003;114:763–776
  58. Oh H , Chi X , Bradfute SB , et al.   Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells . Ann NY Acad Sci . 2004;1015:182–189
  59. Urbanek K , Torella D , Sheikh F , et al.   Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure . Proc Natl Acad Sci USA . 2005;102(24):8692–8697 2005 Epub June 2
  60. Oh H , Bradfute SB , Gallardo TD , et al.   Cardiac progenitor cells from adult myocardium (homing, differentiation, and fusion after infarction) . Proc Natl Acad Sci USA . 2003;100:12313–12318
  61. Hutcheson KA , Atkins BZ , Hueman MT , et al.   Comparison of benefits on myocardial performance of cellular cardiomyoplasty with skeletal myoblasts and fibroblasts . Cell Transplant . 2000;9:359–368
  62. Agbulut O , Vandervelde S , Al Attar N , et al.   Comparison of human skeletal myoblasts and bone marrow-derived CD133+ progenitors for the repair of infarcted myocardium . J Am Coll Cardiol . 2004;44:458–463
  63. Reinecke H , Zhang M , Bartosek T , et al.   Survival, integration, and differentiation of cardiomyocyte grafts (a study in normal and injured rat hearts) . Circulation . 1999;100:193–202
  64. Ott HC , Bonaros N , Marksteiner R , et al.   Combined transplantation of skeletal myoblasts and bone marrow stem cells for myocardial repair in rats . Eur J Cardiothorac Surg . 2004;25:627–634
  65. Menasche P , Hagege AA , Scorsin M , et al.   Myoblast transplantation for heart failure . Lancet . 2001;357:279–280
  66. Dib N , McCarthy P , Campbell A , et al.   Feasibility and safety of autologous myoblast transplantation in patients with ischemic cardiomyopathy . Cell Transplant . 2005;14:11–19
  67. Smits PC , van Geuns RJ , Poldermans D , et al.   Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure (clinical experience with six-month follow-up) . J Am Coll Cardiol . 2003;42:2063–2069
  68. Herreros J , Prosper F , Perez A , et al.   Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction . Eur Heart J . 2003;24:2012–2020
  69. Siminiak T , Kalawski R , Fiszer D , et al.   Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury (phase I clinical study with 12 months of follow-up) . Am Heart J . 2004;148:531–537
  70. Stamm C , Westphal B , Kleine HD , et al.   Autologous bone-marrow stem-cell transplantation for myocardial regeneration . Lancet . 2003;361:45–46
  71. Stamm C , Kleine HD , Westphal B , et al.   CABG and bone marrow stem cell transplantation after myocardial infarction . Thorac Cardiovasc Surg . 2004;52:152–158
  72. Hamano K , Nishida M , Hirata K , et al.   Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease (clinical trial and preliminary results) . Jpn Circ J . 2001;65:845–847
  73. Schachinger V , Assmus B , Britten MB , et al.   Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (final one-year results of the TOPCARE-AMI Trial) . J Am Coll Cardiol . 2004;44:1690–1699
  74. Assmus B , Schachinger V , Teupe C , et al.   Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI) . Circulation . 2002;106:3009–3017
  75. Tse HF , Kwong YL , Chan JK , et al.   Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation . Lancet . 2003;361:47–49
  76. Fuchs S , Satler LF , Kornowski R , et al.   Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease (a feasibility study) . J Am Coll Cardiol . 2003;41:1721–1724
  77. Perin EC , Dohmann HF , Borojevic R , et al.   Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure . Circulation . 2003;107:2294–2302
  78. Perin EC , Dohmann HF , Borojevic R , et al.   Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy . Circulation . 2004;110:II213–II218
  79. Britten MB , Abolmaali ND , Assmus B , et al.   Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI) (mechanistic insights from serial contrast-enhanced magnetic resonance imaging) . Circulation . 2003;108:2212–2218
  80. Fernandez-Aviles F , San Roman JA , Garcia-Frade J , et al.   Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction . Circ Res . 2004;95:742–748
  81. Kuethe F , Richartz BM , Sayer HG , et al.   Lack of regeneration of myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans with large anterior myocardial infarctions . Int J Cardiol . 2004;97:123–127
  82. Wollert KC , Meyer GP , Lotz J , et al.   Intracoronary autologous bone-marrow cell transfer after myocardial infarction (the BOOST randomised controlled clinical trial) . Lancet . 2004;364:141–148
  83. Chen SL , Fang WW , Ye F , et al.   Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction . Am J Cardiol . 2004;94:92–95
  84. Vanderheyden MMS , Vandekerckhove B , De Bondt P , et al.   Selected intracoronary CD133+ bone marrow cells promote cardiac regeneration after acute myocardial infarction . Circulation . 2004;110:324–325
  85. Wollert KC , Drexler H . Clinical applications of stem cells for the heart . Circ Res . 2005;96:151–163
  86. Janssens S . Intracoronary Autologous Bone-Marrow Cell Transfer after Myocardial Infarction (A Double-Blind, Randomized, and Placebo-Controlled Clinical Trial) . American College of Cardiology Scientific Sessions . 2005;
  87. Itescu S , Kocher AA , Schuster MD . Myocardial neovascularization by adult bone marrow-derived angioblasts (strategies for improvement of cardiomyocyte function) . Heart Fail Rev . 2003;8:253–258
  88. Horackova M , Arora R , Chen R , et al.   Cell transplantation for treatment of acute myocardial infarction (unique capacity for repair by skeletal muscle satellite cells) . Am J Physiol Heart Circ Physiol . 2004;287:H1599–H1608
  89. Suzuki K , Murtuza B , Smolenski RT , et al.   Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts . Circulation . 2001;104:I207–I212
  90. Suzuki K , Brand NJ , Allen S , et al.   Overexpression of connexin 43 in skeletal myoblasts (Relevance to cell transplantation to the heart) . J Thorac Cardiovasc Surg . 2001;122:759–766
  91. Mangi AA , Noiseux N , Kong D , et al.   Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts . Nat Med . 2003;9:1195–1201
  92. Shake JG , Gruber PJ , Baumgartner WA , et al.   Mesenchymal stem cell implantation in a swine myocardial infarct model (engraftment and functional effects) . Ann Thorac Surg . 2002;73:1919–1925 discussion, 1926
  93. Beauchamp JR , Pagel CN , Partridge TA . A dual-marker system for quantitative studies of myoblast transplantation in the mouse . Transplantation . 1997;63:1794–1797
  94. Ellis MRS , Taylor D . Translating cell transfer for cardiovascular disease to the bedside (a pre-clinical review and discussion of potential early trials) . Cardiac. Vasc Regen . 2000;3:197–203
  95. Zhang M , Methot D , Poppa V , et al.   Cardiomyocyte grafting for cardiac repair (graft cell death and anti-death strategies) . J Mol Cell Cardiol . 2001;33:907–921
  96. Suzuki K , Smolenski RT , Jayakumar J , et al.   Heat shock treatment enhances graft cell survival in skeletal myoblast transplantation to the heart . Circulation . 2000;102:III216–III221

PII: S1043-0679(05)00074-2

doi: 10.1053/j.semtcvs.2005.09.004

Seminars in Thoracic and Cardiovascular Surgery
Volume 17, Issue 4 , Pages 348-360 , Winter 2005

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