Seminars in Thoracic and Cardiovascular Surgery
Volume 20, Issue 2 , Pages 126-130 , Summer 2008

Intraoperative Cell Transplantation for Congestive Heart Failure: Experience in China

  • Hao Zhang, MD, PhD
    • ,
  • Ying-jie Wei, PhD
    • ,
  • Sheng-shou Hu, MD, FACC

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Sheng-shou Hu, MD, FACC, Department of Cardiac Surgery, Research Center for Cardiac Regenerative Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 167A Beilishilu, Beijing 100037, P.R. China

References 

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  2. Chinese Association of Cardiology. Retrospective investigation of hospitalized patients with heart failure in some parts of China in 1980, 1990 and 2000. Chin J Cardiol. 2002;30:450–454
  3. Zhu HS, Zhong H, Wei HC. Autologous myoblast transplantation for the treatment of acute myocardial infarction. Nation Med J Chin. 2000;80:873–875
  4. Hou M, Yang KM, Zhang H, et al. Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats. Int J Cardiol. 2007;115:220–228
  5. Zhang H, Fazel S, Tian H, et al. Increasing donor age adversely impacts beneficial effects of bone marrow but not smooth muscle myocardial cell therapy?. Am J Physiol Heart Circ Physiol. 2005;289:H2089–H2096
  6. Zhang SJ, Zhang H, Wei YJ, et al. Adult endothelial progenitor cells from human peripheral blood maintain monocyte macrophage function throughout in vitro culture. Cell Res. 2006;16:577–584
  7. Zhang SJ, Zhang H, Mai H, et al. Is it possible to obtain true endothelial progenitor cells by in vitro culture of bone marrow mononuclear cells?. Stem Cell Develop. 2007;16:683–69
  8. Su W, Zhang H, Jia Z, et al. Cartilage-derived stromal cells: is it a novel cell resource for cell therapy to regenerate infarcted myocardium?. Stem Cells. 2006;24:349–356
  9. Yuan X, Zhang H, Wei YJ, et al. Embryonic stem cell transplantation for the treatment of myocardial infarction: immune privilege or rejection. Transplant Immunol. 2007;18:88–93
  10. Zhang H, Zhu SJ, Wang W, et al. Transplantation of microencapsulated genetically modified xenogenic cells augments angiogenesis and improves heart function. Gene Ther. 2008;15:40–48
  11. Zhang H, Song P, Tang Y, et al. Injection of bone marrow mesenchymal stem cells in the borderline area of infarcted myocardium: heart status and cell distribution. J Thorac Cardiovasc Surg. 2007;134:1234–1240
  12. Kindi A, Chen GY, Asenjo JF. Cellular cardiomyoplasty: optimizing cellular dosage and retention by microencapsulation. Circulation. 2007;116:II591
  13. Li RK, Jia ZQ, Weisel RD. Survival and function of bioengineered cardiac grafts. Circulation. 1999;100:II63–II69
  14. Zhang P, Zhang H, Wang H, et al. Artificial matrix help neonatal cardiomyocytes restore injured myocardium in rats. Artificial Organs. 2006;30:86–89
  15. Zhang F, Yang Z, Chen Y, et al. Clinical cellular cardiomyoplasty: technical considerations. J Card Surg. 2003;18:268–273
  16. Ge J. Current status of clinical studies of cell therapy for the heart disease in China. Chin J Cardiol. 2006;34:97–98
  17. Zhao Q, Sun YX, Xia LM, et al. Transplantation of autologous bone marrow mononuclear cells during coronary bypass surgery for patients with myocardial infarction: a preliminary clinical study. Chin J Thorac Cardiovasc Surg. 2006;122:212–213
  18. Stem cell therapy to improve myocardial function in patients undergoing coronary artery bypass grafting (CABG). http://www.clinicaltrials.gov/ct2/show/NCT00395811Accessed April 17, 2008
  19. He G, Zhang H, Wei H, et al. In vivo imaging of bone marrow mesenchymal stem cells transplanted into myocardium using magnetic resonance imaging: a novel method to trace the transplanted cells. Int J Cardiol. 2007;114:4–10

 This study was supported by the Program for Changjiang Scholars and the Innovative Research Team in University, National Scientific Foundation of China (30500498) and Beijing Nova Project (2006A85).

PII: S1043-0679(08)00044-0

doi: 10.1053/j.semtcvs.2008.03.002

Seminars in Thoracic and Cardiovascular Surgery
Volume 20, Issue 2 , Pages 126-130 , Summer 2008

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