Seminars in Thoracic and Cardiovascular Surgery
Volume 20, Issue 2 , Pages 115-118 , Summer 2008

MSC Immune Tolerance in Cellular Cardiomyoplasty

  • Ray Chu-Jeng Chiu, MD, PhD, FRCSC

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Ray Chu-Jeng Chiu, MD, PhD, FRCSC, The Montreal General Hospital, MUHC, Suite C9-169, 1650 Cedar Avenue, Montreal, PQ, Canada H3G 1A4

References 

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  2. Liechty KW, MacKenzie TC, Shaaban A, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Med. 2000;6:1282–1286
  3. Saito T, Kuang J-Q, Bittira B, et al. Xenotransplant cardiac chimera: immune tolerance of adult stem cells. Ann Thorac Surg. 2002;74:19–24
  4. MacDonald DJ, Saito T, Shum-Tim D, et al. Persistence of marrow stromal cells implanted into acutely infracted myocardium: observations in a xenotransplant model. J Thorac Cardiovasc Surg. 2005;130:1114–1121
  5. Atoui R, Asenjo J-F, Duong M, et al. Marrow stromal cells as “universal donor cells” for myocardial regenerative therapy: their unique immune tolerance. Ann Thorac Surg. 2008;85:571–580
  6. Dai W, Hale S, Martin B, et al. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation. 2005;112:214–223
  7. Amado LC, Saliaris AP, Schuleri KH, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. PNAS. 2005;102:11474–11479
  8. Zambrano J, Traverse JH, Henry T, et al. The impact of intravenous allogeneic human mesenchymal stem cells (Provacel™) on ejection fraction in patients with myocardial infarction. Circulation. 2007;116:II-202
  9. Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood. 2007;110:3499–3506
  10. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005;105:1815–1822
  11. Wang JS, Shum-Tim D, Galipeau J, et al. Marrow stromal cells for cellular cardiomyoplasty: feasibility and clinical advantages. J Thorac Cardiovasc Surg. 2000;120:999–1006
  12. Le Blanc K, Tammik C, Rosendahl K, et al. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exper Hematol. 2003;31:890–896
  13. Liu CT, Yang YJ, Yin F, et al. The immunobiological development of human bone marrow mesenchymal stem cells in the course of neuronal differentiation. Cellular Immunol. 2006;244:19–32
  14. Chiu R. “Stealth immune tolerance” in stem cell transplantation: potential for “universal donors” in myocardial regenerative therapy. J Heart Lung Transplant. 2005;24:511–516
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  16. Poncelet A, Vercruysse J, Saliez A, et al. Although pig allogeneic mesenchymal stem cells are not immunogenic in vitro, intracardiac injection elicits an immune response in vivo. Transplantation. 2007;83:783–790
  17. Grinnemo KH, Mansson A, Dellgren G, et al. Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infracted rat myocardium. J Thorac Cardiovasc Surg. 2004;127:1293–1300
  18. Grinnemo KH, Mansson-Broberg A, Le Blanc K, et al. Human mesenchymal stem cells do not differentiate into cardiomyocytes in a cardiac ischemic xenomodel. Ann Med. 2006;38:144–153
  19. Kofidis T, deBruin , Zwierzchoniewska M, et al. They are not stealthy in the heart: embryonic stem cells trigger cell infiltration, humoral and T-based lymphocyte host immune response. Eur J Cardiothorac Surg. 2005;28:461–466
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PII: S1043-0679(08)00055-5

doi: 10.1053/j.semtcvs.2008.03.004

Seminars in Thoracic and Cardiovascular Surgery
Volume 20, Issue 2 , Pages 115-118 , Summer 2008

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