Seminars in Thoracic and Cardiovascular Surgery
Volume 21, Issue 2 , Pages 154-158, Summer 2009

Current Options for Systemic Therapy in Mesothelioma

  • David M. Jackman, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to David M. Jackman, MD, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115

Dana-Farber Cancer Institute, Boston, Massachusetts

Systemic therapy options for patients with mesothelioma remain limited. Although many conventional chemotherapeutic agents have shown modest activity in this disease, only the combination of cisplatin plus pemetrexed has demonstrated an improvement in clinical outcomes in a phase III trial when compared with single modality therapies. Clinical investigations of the use of targeted therapies in mesothelioma are ongoing, as investigators attempt to inhibit critical pathways in this disease. This article surveys the current clinical landscape of systemic therapies in mesothelioma and explores the impact of both conventional and targeted agents.

Keywords: mesothelioma, chemotherapy

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 This work was supported by the Alice and Stephen D. Cutler Investigator Fund in Thoracic Oncology at Dana-Farber Cancer Institute.

 Dr. Jackman has served on an advisory board to Genentech and has received honoraria from Roche.

PII: S1043-0679(09)00074-4

doi:10.1053/j.semtcvs.2009.06.010

Seminars in Thoracic and Cardiovascular Surgery
Volume 21, Issue 2 , Pages 154-158, Summer 2009

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