Lack of information about rate and completeness of Xeltis conduit resorption and strength
and persistent functionality of the substituting autologous tissue require longer
follow-up.
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References
- Initial clinical trial of a novel pulmonary valved conduit.Semin Thorac Cardiovasc Surg. 2022; 34: 985-991
- A novel restorative pulmonary valved conduit in a chronic sheep model: Mid-term hemodynamic function and histologic assessment.J Thorac Cardiovasc Surg. 2018; 155: 2591-2601
- A Novel Restorative Pulmonary Valve Conduit: Early Outcomes of Two Clinical Trials.Front Cardiovasc Med. Accept Publ. 2021;
Article info
Publication history
Published online: May 15, 2021
Footnotes
Conflict of Interest: There is no potential conflict of interest.
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© 2021 Elsevier Inc. All rights reserved.
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- Initial Clinical Trial of a Novel Pulmonary Valved ConduitSeminars in Thoracic and Cardiovascular SurgeryVol. 34Issue 3
- PreviewValved allografts and xenografts for reconstruction of the right ventricular outflow tract (RVOT) lack durability and do not grow. We report the first clinical use of a completely bioabsorbable valved conduit (Xeltis pulmonary valve - XPV) in children. Twelve children (six male), median age five (two to twelve) years and median weight 17 (10 to 43) kg, underwent RVOT reconstruction with the XPV. Diagnoses were: pulmonary atresia with ventricular septal defect (VSD) (n = 4), tetralogy of Fallot (n = 4), common arterial trunk (n = 3), and transposition of the great arteries with VSD and pulmonary stenosis (n = 1).
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