Commentary: Women are Not Just Men Without the Y Chromosome

  • Lauren C. Kane
    Address reprint requests to: Lauren C. Kane, MD, Children's Hospital New Orleans, 200 Henry Clay Ave, New Orleans, LA 70118.
    Department of Surgery, Congenital Heart Center, Children's Hospital New Orleans, New Orleans, Los Angeles
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      Women patients with cardiovascular disease experience treatment bias, delayed referrals, and impaired access to care. Women are more likely to die following CABG compared to men.
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        • Nowbar A.N.
        • Gitto M.
        • Howard J.P.
        • Francis D.P.
        • Al-Lamee R.
        Mortality from ischemic heart disease.
        Circ Cardiovasc Qual Outcomes. 2019; 12e005375
        • Benjamin E.J.
        • Virani Salim
        • Callaway Clifton
        • et al.
        • American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee.
        Heart Disease and Stroke Statistics-2018 Update: A Report from the American Heart Association.
        Circulation. 2018; 137: e67-e492
        • Ram E.
        • Sternik L.
        • Moshkovitz Y.
        Coronary artery bypass grafting following acute coronary syndrome: Impact of gender.
        Semin Thorac Cardiovasc Surg. 2022; 34: 920-929
        • Daly C.
        • Clemens F.
        • Lopez Sendon J.L.
        • et al.
        Gender differences in the management and clinical outcome of stable angina.
        Circulation. 2006; 113: 490-498
        • Mosca L.
        • Linfante A.H.
        • Benjamin E.J.
        • et al.
        National study of physician awareness and adherence to cardiovascular disease prevention guidelines.
        Circulation. 2005; 111: 499-510
        • Chandra N.C.
        • Ziegelstein R.C.
        • Rogers W.J.
        • et al.
        Observations of the treatment of women in the United States with myocardial infarction: A report from the national registry of myocardial infarction-I.
        Archives Int Med. 1998; 158: 981-988
        • Tsang T.S.
        • Barnes M.E.
        • Gersh B.J.
        • et al.
        Risks of coronary heart disease in women: current understanding and evolving concepts.
        Mayo Clinic Proc. 2000; 75: 1289-1303
        • Guru V.
        • Fremes S.E.
        • Austin P.C.
        • Blackstone E.H.
        • Tu J.V.
        Gender differences in outcomes after hospital discharge from coronary artery bypass grafting.
        Circulation. 2006; 113: 507-516
        • Murphy M.L.
        • Hultgren H.N.
        • Detre K.
        • Thomsen J.
        • Takaro T.
        Treatment of chronic stable angina. A preliminary report of survival data of the randomized Veterans Administration cooperative study.
        N Engl J Med. 1977; 297: 621-627
        • Harris D.J.
        • Douglas P.S.
        Enrollment of women in cardiovascular clinical trials funded by the National Heart, Lung, and Blood Institute.
        N Engl J Med. 2000; 343: 475-480
        • Kim E.S.H.
        • Carrigan T.P.
        • Menon V.
        Enrollment of women in National Heart, Lung, and Blood Institute - funded cardiovascular randomized controlled trials fails to meet current federal mandates for inclusion.
        JACC. 2008; 52: 672-673
        • Melloni C.
        • Berger J.S.
        • Wang T.Y.
        • et al.
        Representation of women in randomized clinical trials of cardiovascular disease prevention.
        Circ Cardiovasc Qual Outcomes. 2010; 3: 135-142
        • Hessian R
        • Jabagi H
        • Ngu J
        • Rubin F
        Coronary Surgery in Women and the Challenges We Face.
        Canadian J Cardiol. 2018; 34: 413
        • Mosca L.
        • Jones W.K.
        • King K.B.
        • et al.
        Awareness, perception, and knowledge of heart disease risk and prevention among women in the United States. American Heart Association women's heart disease and stroke campaign task force.
        Arch Fam Med. 2000; 9: 516-517
        • Mosca L.
        • Williams C.L.
        • et al.
        American Heart Association. Evidence-based guidelines for cardiovascular disease prevention in women.
        Circulation. 2004; 109: 672-693
        • Garcia M.
        • Mulvagh S.L.
        • Merz C.N.
        • Buring J.E.
        • Manson J.E.
        Cardiovascular disease in women: Clinical perspectives.
        Circ Res. 2016; 118: 1273-1293
        • Roger V.L.
        • Go A.S.
        • Lloyd-Jones D.M.
        • et al.
        Heart disease and stroke statistics -2011 update, A report from the American Heart Association.
        Circulation. 2011; 123: e18-e209

      Linked Article

      • Coronary Artery Bypass Grafting Following Acute Coronary Syndrome: Impact of Gender
        Seminars in Thoracic and Cardiovascular SurgeryVol. 34Issue 3
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          The impact of gender on clinical outcomes after coronary artery bypass grafting (CABG) has generated conflicting results. We investigated the impact of gender, on 30 day mortality, complications and late survival in patients with acute coronary syndrome (ACS) undergoing CABG. The study included 1308 patients enrolled from the biennial Acute Coronary Syndrome Israeli Survey between 2000 and 2016, who were hospitalized for ACS and underwent CABG. Of them, 1045 (80%) were men and 263 (20%) women. While women were older and had more hypertension and hyperlipidemia, they demonstrated less diabetes mellitus, previous ischemic heart disease, smoking, and fewer implicated coronary arteries.
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