Commentary: Can Patients with Bicuspid Aortopathy Be Ultimately Cured?

  • Natalie Glaser
    Address reprint requests to Natalie Glaser, MD, PhD. Department of Cardiology, Stockholm South General Hospital, Sjukhusbacken 10, SE-118 83 Stockholm, Sweden.
    Department of Cardiology, Stockholm South General Hospital, Stockholm, Sweden

    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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      Patients with bicuspid aortic valves who undergo AVR have excellent prognosis. Future research should focus on the risk of aortic events in patients with bicuspid valves and aortic regurgitation.
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        • Sun J
        • Chen C
        • Sun C
        • et al.
        Outcomes after isolated aortic valve replacement in patients with bicuspid versus tricuspid aortic valve.
        Semin Thorac Cardiovasc Surg. 2022; 34: 854-865
        • Glaser N
        • Jackson V
        • Eriksson P
        • et al.
        Relative survival after aortic valve surgery in patients with bicuspid aortic valves.
        Heart. 2021; Jul;107: 1167-1172
        • Holmgren A
        • Enger TB
        • Naslund U
        • et al.
        Long-term results after aortic valve replacement for bicuspid or tricuspid valve morphology in a Swedish population.
        Eur J Cardiothorac Surg. 2021; 59: 570-576
        • Wang Y
        • Wu B
        • Li J
        • et al.
        Impact of aortic insufficiency on ascending aortic dilatation and adverse aortic events after isolated aortic valve replacement in patients with a bicuspid aortic valve.
        Ann Thorac Surg. 2016; 101: 1707-1714
        • Girdauskas E
        • Rouman M
        • Disha K
        • et al.
        Aortic dissection after previous aortic valve replacement for bicuspid aortic valve disease.
        J Am Coll Cardiol. 2015; 66: 1409-1411
        • Huntley GD
        • Thaden JJ
        • Alsidawi S
        • et al.
        Comparative study of bicuspid vs. Tricuspid aortic valve stenosis.
        Eur Heart J Cardiovasc Imaging. 2018; 19: 3-8
        • Borger MA
        • Fedak PWM
        • Stephens EH
        • et al.
        The American association for thoracic surgery consensus guidelines on bicuspid aortic valve-related aortopathy: Full online-only version.
        J Thorac Cardiovasc Surg. 2018; 156: e41-e74

      Linked Article

      • Outcomes After Isolated Aortic Valve Replacement in Patients with Bicuspid vs Tricuspid Aortic Valve
        Seminars in Thoracic and Cardiovascular SurgeryVol. 34Issue 3
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          To compare the outcomes in patients undergoing isolated aortic valve replacement with bicuspid (BAV) vs tricuspid aortic valves (TAV). A total of 1204 consecutive patients (BAV, n = 454; TAV, n = 750) underwent isolated aortic valve replacement (AVR) between 2002 and 2009 at a single institution. Adverse aortic events were defined as the occurrence of aortic dissection or the ascending aorta diameter greater than 50 mm or sudden death during follow-up. Propensity score matching yielded 318 patient pairs.
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