In vitro and in vivo models provide the better knowledge on the pathogenesis of esophagitis-Barret’-carcinoma progression that can results in promising treatment strategies for esophageal cancer.
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Published online: September 12, 2021
Conflicts of Interest: No conflict of interests to disclose.
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- Toll-like Receptor 4 Mediates Reflux-Induced Inflammation in a Murine Reflux ModelSeminars in Thoracic and Cardiovascular SurgeryVol. 34Issue 4
- PreviewDysregulation of toll-like receptor (TLR) signaling within the gastrointestinal epithelium has been associated with uncontrolled inflammation and tumorigenesis. We sought to evaluate the role of TLR4 in the development of gastroesophageal reflux-mediated inflammation and mucosal changes of the distal esophagus. Verified human esophageal Barrett's cells with high grade dysplasia (CPB) and esophageal adenocarcinoma cells (OE33) were treated with deoxycholic acid for 24 hours. Cells were pretreated with a TLR4-specific inhibitor peptide 2 hours prior to deoxycholic acid treatment.