Abbreviations:T3 (Triiodothyronine), CPB (Cardiopulmonary bypass), TTE (Time to Extubation), TRICC (Triiodothyronine during Cardiopulmonary bypass in Infants and Children)
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Funding: Funding was provided by the U.S Food and Drug Administration Office of Orphan Product Development by Grant R01 FD004362 to M.A.P.
INSTITUTIONAL REVIEW BOARD FWA00002443, Approval 14798, October 17, 2013.
Parents of subjects provided informed consent for participation in this trial.
Disclosures: The authors have no financial conflicts to disclose.
Conflicts of interest: The authors have no conflicts of interest to disclose.
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- Commentary: The Trials and Tribulations of T3 SupplementationSeminars in Thoracic and Cardiovascular SurgeryVol. 35Issue 1
- PreviewIn this issue of Seminars, Portman and colleagues report the results of a 3-center, randomized, controlled trial (RCT) of triiodothyronine (T3) supplementation in infants <152 days old undergoing cardiac surgery with cardiopulmonary bypass (CPB).1 They randomized 220 infants (103 neonates) and found no difference in their primary endpoint, time to extubation, or any secondary endpoints including vasoactive score, ICU length of stay (LOS), or presence of low cardiac output. This rigorously conducted RCT represents the culmination of years of work by the investigative team seeking to understand the potential benefits of T3 supplementation.