Chest tubes account for a large proportion of postoperative pain after cardiothoracic
operations. The objective of this study was to develop a novel, cost-effective, easy-to-use,
lidocaine-eluting coating to reduce pain associated with postoperative chest tubes.
A lidocaine-eluting hydrogel was developed by dispersing lidocaine-loaded nanoparticles
in an aqueous solution containing gelatin (5%). Glutaraldehyde (1%) was added to crosslink
the gelatin into a hydrogel. The hydrogel was dehydrated, resulting in a thin, stable
polymer. Sterile lidocaine hydrogel-coated silicone discs and control discs were prepared
and surgically implanted in the subcutaneous space of C57B6 mice. Using von Frey filaments,
mice underwent preoperative baseline pain testing, followed by pain testing on post-procedure
day 1 and 3. On post-procedure day 1, mice implanted with control discs demonstrated
no change in pain tolerance compared to baseline, while mice implanted with 20 mg
and 80 mg lidocaine-loaded discs demonstrated a 2.4-fold (P = 0.36) and 4.7-fold (P = 0.01) increase in pain tolerance, respectively. On post-procedure day 3, mice implanted
with control discs demonstrated a 0.7-fold decrease in pain tolerance compared to
baseline, while mice implanted with 20 mg and 80 mg lidocaine-loaded discs demonstrated
a 1.8-fold (P = 0.88) and 8.4-fold (P = 0.02) increase in pain tolerance, respectively. Our results demonstrate successful
development of a lidocaine-eluting chest tube with hydrogel coating, leading to improved
pain tolerance in vivo. The concept of a drug-eluting drain coating has significant importance due to its
potential universal application in a variety of drain types and insertion locations.
Graphical Abstract
Graphical Abstract
Keywords
Abbreviations:
DMF (N,N-Dimethylformamide), DMSO (Dimethyl sulfoxide), PEG-PSHU-PEG (Poly(ethylene glycol)-block- poly(serinol hexamethylene urea)-block-poly(ethylene glycol)), PBS (Phosphate-buffered saline)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: September 19, 2022
Publication stage
In Press Journal Pre-ProofFootnotes
Disclosures: The authors have no conflicts of interest.
Funding: This work was supported by NIH/NCATS Colorado CTSA (grant number UL1 TR002535) and the University of Colorado Department of Surgery Academic Enrichment Fund.
Read at the 48th Annual Meeting of the Western Thoracic Surgical Association, June 22-25, 2022, Koloa Hawaii.
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