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T3N0M0 NSCLC Subtypes - A Signal for Disparate Outcomes after Surgery

  • Dana Ferrari-Light
    Affiliations
    Thoracic Surgery Division, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio
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  • Peter J. Kneuertz
    Correspondence
    Address reprint requests to Peter J. Kneuertz, MD, FACS, Thoracic Surgery Division, Department of Surgery, The Ohio State University Wexner Medical Center, Doan Hall N846, 410 West 10th Avenue, Columbus, OH 43210, Phone: (614) 293-9059, Fax: (614) 293-3453.
    Affiliations
    Thoracic Surgery Division, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio
    Search for articles by this author
Published:September 20, 2022DOI:https://doi.org/10.1053/j.semtcvs.2022.09.003
      The current T3N0M0 stage includes a variety of locally advanced tumor features that may be associated with disparate outcomes after surgery and should be re-examined in the era of immunotherapy.

      Abbreviations:

      CWI (Chest wall invasion), IASLC (International Association for the Study of Lung Cancer), NSCLC (Non-small cell lung cancer)
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      Linked Article

      • Oncologic Outcomes of Patients With Resected T3N0M0 Non-small Cell Lung Cancer
        Seminars in Thoracic and Cardiovascular Surgery
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          In the eighth edition TNM staging, the T3N0M0 category represents a heterogeneous group of non-small cell lung cancers (NSCLC). This study aims to compare the oncologic outcomes associated with individual T3 features. We performed a single-institution, retrospective analysis of 280 consecutive patients with pT3N0M0 NSCLC. Multivariate regression models were used to estimate associations of clinical factors with oncologic outcomes. The patients were grouped according to their T3 features into 4 prognostic groups: chest wall infiltration (CWI-PG), largest diameter >5 cm and ≤7 cm (Size-PG), presence of a satellite nodule (SN-PG), and all other T3 features.
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